Notably, Spark has exclusive rights to commercialize CHOP's proprietary manufacturing technology and will use clinical . When typing in this field, a list of search results will appear and be automatically updated as you type. NGK 2625: 12 mm x 1.25 mm:. Under the terms of the agreement, Spark will receive an upfront payment of $20 million and will be eligible for additional development and commercialization milestone payments of up to $260 million for multiple hemophilia B product candidates that may be developed under the collaboration. Which investors participated in the most funding rounds? Seed, Series A, Private Equity), Whether an Organization is for profit or non-profit, General contact email for the organization, Auto-generated name of transaction (e.g. Spark Therapeutics, Inc. focuses on the development of gene therapy products for patients suffering from debilitating genetic diseases. Get company contacts Their latest funding was raised on May 27, 2014 from a Series B round. Types of diversity represented in an organization, specifically of those who are founding members, currently the CEO, or have check-writing abilities in an investment firm. About Spark Therapeutics. Spark Therapeutics has acquired Genable Technologies Ltd. on Mar 7, 2016. Spark Therapeutics is actively using 64 technologies for its website, according to BuiltWith. Navigate a database of ~2k spark plugs and cross - reference products for them. If successful, gene therapy in hemophilia B would eliminate or reduce the need for regular infusions of clotting factor, enabling physicians to provide comprehensive, accessible treatment to all hemophilia B patients, potentially including those with inhibiting antibodies. Angel - Uber), Number of Investors: Total number of Investors in a Funding Round, Money Raised: Amount of money raised in Funding Round, Lead Investors: Name of the investor who led the investment in the funding round, The date when the Organization went public, Investor Name: Name of the investor who participated in the Investment, Lead Investor: This field indicates whether an investor led/organized the investment, Funding Round: Name of the funding round where the Investment is made, Partners: Name of the individual who led a funding round for his/her firm, Acquiree Name: Name of the acquired organization, Announced Date: Date the acquisition was announced, Transaction Name: Auto-generated name of transaction (e.g. The founding team includes scientists who led the movement to develop gene therapy as a new treatment paradigm, establishing clinical proof of concept in the eye and liver and contributing key insights to the field that have resulted in a resurgence of industry interest in gene-based medicines. Spark Therapeutics to Invest $575M in New 500k Square Foot State-of-the-Art Gene Therap.. The organisation is a fully integrated, commercial company committed to discovering, developing and delivering gene therapies for genetic diseases, including inherited retinal disorders, haemophilia, lysosomal storage disorders and neurodegenerative diseases. Spark's proprietary, bioengineered vectors are designed to deliver a high-activity Factor IX gene to patients, enabling endogenous production of Factor IX, with the potential to be effective for a number of years. Part # 7034. When typing in this field, a list of search results will appear and be automatically updated as you type. Spark has rights to a proprietary manufacturing platform that has a track record supporting clinical studies across diverse therapeutic areas and routes of administration. Leading gene therapy Company will partner with established market leader to develop a potential new treatment paradigm for hemophilia B. PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today that it has entered into a global collaboration with Pfizer Inc. for the development and potential commercialization of SPK-FIX, a development program advancing proprietary, bio-engineered adeno-associated virus (AAV) vectors for the potential treatment of hemophilia B. About Spark Therapeutics . Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American, www.sparktx.com/pipeline/hematologic-disorders, http://www.prnewswire.com/news-releases/spark-therapeutics-announces-gene-therapy-collaboration-in-hemophilia-b-with-pfizer-inc-300005849.html. Where the organization is headquartered (e.g. "Filtering down to just Philadelphia proper does reveal that . "With their experience in the field of gene therapy, as well as in the research and development of potential novel treatments for hemophilia, we believe that Spark's team of scientists and clinicians will complement Pfizer's expertise in helping to bring a new therapy to patients," said Kevin Lee, senior vice president and chief scientific officer, Rare Disease Research Unit, Pfizer. The Spark team was among the first to demonstrate human clinical proof of concept in two distinct organ systemsthe eye and the liverestablishing a strong foundation for the company's current programs, and has clinical experience in 15 studies across diverse genetic and non-genetic diseases and five distinct routes of administration. All news about SPARK THERAPEUTICS INC. CombiGene's and Neurochase's preclinical study provides valuable information for the up.. GMP production of CG01 made available for preclinical studies planned to enable First i.. Dr. Hanadie Yousef is a scientist with expertise in stem cell, neuro and aging biology, and the co-founder and CEO of Juvena Therapeutics, a computationally driven protein drug discovery . SPK-FIX leverages a long track record of hemophilia B gene therapy research conducted by Spark and its founding scientific team which, in prior clinical trials, has demonstrated safety and proof-of-concept in expressing Factor IX in the liver. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Find More Contacts for Spark Therapeutics, Diversity Spotlight (US Headquarters Only), Edit Lists Featuring This Company Section, Chroma Medicine Welcomes Spark Therapeutics Co-Founder and Former Founding CEO Jeff Marrazzo to Board of Directors, Power Moves: CEO Jeff Marrazzo is leaving Spark Therapeutics, 3 years after that giant acquisition, Spark Therapeutics Announces Departure of CEO and Founder Jeff Marrazzo; COO Ron Philip Named as Successor, Northeastern US Acquired Companies With More Than $1B in Revenue, Great Lakes Acquired Companies With More Than $10M in Revenue, Great Lakes Companies With More Than $1B in Revenue, Pennsylvania Acquired Companies With More Than $50M in Revenue. The founding team includes scientists who have led the advancement of gene therapy over the past two decades, establishing human proof of concept of the expression of gene. Head of Corporate Security. Spark's initial focus is on treating orphan diseases where no, or only palliative therapies, exist. Spark is a gene therapy leader seeking to transform the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. Phone Number +1 215-220-9300. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Acting Vice-Chair for Education, Department of Neurology. Oversee the development of medical strategies for Spark products that can be used to guide developme. Iowa City, Iowa, United States. PHILADELPHIA, Nov. 6, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today that its lead product . WhatsApp acquired by Facebook). Dec 08, 2014, 07:30 ET. . For more information on Spark Therapeutics and its clinical pipeline, including SPK-FIX, please visit www.sparktx.com. Spark will assume control over two gene therapy clinical trials: a Phase 3 study for inherited blindness caused by mutations of the RPE65 gene and a Phase 1/2 study for hemophilia B. The open-label, dose escalation study is designed to assess safety and effectiveness of gene therapy in inducing the body to create native factor IX, as measured in their blood. Associate Professor of Neurology. The Gene Therapy Medicinal Products (GTMP) Market research report includes Market segmentation and overlays shadow upon the leading market players highlighting the favourable competitive landscape and trends prevailing over the years. What are the highest paying jobs at. Mutations in the RPE65 gene lead to reduced or absent levels of RPE65 isomerohydrolase activity, blocking the visual cycle and resulting in progressive vision loss and ultimately, blindness [1]. . Spark Therapeutics does not accept unsolicited resumes/candidate . Spark Therapeutics's new tradmarks suggest it is investing in R&D . About Spark TherapeuticsSpark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Contact Email info@sparktx.com. We look forward to working with Pfizer with the goal of making gene therapy for hemophilia B a reality for patients.". "The collaboration also marks another milestone for Spark, following our recent clinical and regulatory progress and key leadership hires.". We are working with great urgency and care to deliver gene therapy products with the potential to transform the lives of those affected by severe genetic diseases.". Philadelphia, Pennsylvania, United States . Please be aware that we do not take any responsibility for accessing such information which may not comply with any legal process, regulation, registration or usage in the country of your origin. Spark Therapeutics is a publicly traded company on NMS using the ticker symbol ONCE. "Their vision and long-term dedication have enabled us to effectively address many of the key challenges facing the field and to emerge with one of the industry's most robust clinical-stage gene therapy pipelines; as well as exclusive rights to commercialize a proprietary manufacturing platform, supply from a world-class manufacturing facility and a founding team with a proven track record of executing safe and effective gene therapy trials for nearly two decades. AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Descriptive keyword for an Organization (e.g. and menstrual hygiene products to women experiencing homelessness . Spark's current valuation leaves room for substantial upside in the following years. The average Spark Therapeutics salary ranges from approximately $93,180 per year for a Research Associate to $158,235 per year for a Senior Scientist.The average Spark Therapeutics hourly pay ranges from approximately $44 per hour for a Research Associate to $66 per hour for a Project Manager.Spark Therapeutics employees rate the overall compensation and benefits package 4.6/5 stars. Which types of acquisition does this organization make most frequently. programs and capabilities needed to deliver its pioneering gene therapy products. Spark builds on the work of CHOP's Center for Cellular and Molecular Therapeutics (CCMT), established in 2004 as a world-class center for gene therapy translational research and manufacturing. Company Type For Profit. It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. Spark Therapeutics, Inc. 3737 Market Street Philadelphia, PA 19104 Phone: 1-855-SPARKTX / +1 215-220-9300 2022 Spark Therapeutics, Inc. P-RPE65-US-450002-10 Enrollment of approximately 20 total study participants is ongoing. Our robust pipeline includes a Phase 3 program in blindness due to mutations in the RPE65 gene and a Phase 1/2 program in hemophilia B, as well as preclinical programs to address neurodegenerative diseases and other retinal degenerative diseases and hematologic disorders. Spark Therapeutics, Inc. focuses on the development of gene therapy products for patients suffering from debilitating genetic diseases. [1] It is a subsidiary of Hoffmann-La Roche . At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of . PHILADELPHIA, Dec. 8, 2014 /PRNewswire/ -- Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating genetic diseases, announced today . Spark Therapeutics - Wikipedia Spark Therapeutics Spark Therapeutics, Inc. is a developer of gene therapy treatments, which treat debilitating genetic diseases. To learn more visit www.sparktx.com. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Trademark applications show the products and services that Spark Therapeutics is developing and marketing. (Animal Production and Products) Association of Research Directors (ARD) 2013 . AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of lead investment firms and individual investors, Total number of investment firms and individual investors, Announced Date: Date that the Funding Round was publicly announced, Transaction Name: Auto-generated name of transaction (e.g. Leading expertise Spark's founding team includes gene therapy scientists and experts in clinical development and manufacturing who have been at the forefront of the effort to advance gene therapy as a viable treatment paradigm for debilitating, incurable diseases. Our mission at Spark Therapeutics is to challenge the inevitability of genetic disease by discovering, developing and delivering potential treatments in ways unimaginableuntil now. Spark Therapeutics has 368 employees, and the revenue per employee ratio is $254,076. SaaS, Android, Cloud Computing, Medical Device). First participant dosed in the RESOLUTE SM trial, a Phase 1/2 dose-escalation study of SPK-3006. Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. Contents 1 History 2 Products and pipeline 2.1 Voretigene neparvovec 2.2 Fidanacogene elaparvovec 2.3 SPK-8011 2.4 SPK-7001 2.5 SPK-3006 Spark Therapeutics, Inc. Apr 2017 - Present 5 years 8 months. San Francisco Bay Area, Silicon Valley), Operating Status of Organization e.g. Lexington, Massachusetts. Director, Neurology Residency Program. Posted 2w ago . Its products include vor etigene neparvovec, which is in Phase III clinical trial for the treatment of genetic blinding conditions called inherited retinal diseases caused by non sex-linked, autosomal recessive . Spark Therapeutics will be responsible for the supply of voretigene neparvovec worldwide under a separate manufacturing and supply agreement with Novartis. Spark's integrated gene therapy platform builds on two decades of research, development and manufacturing at The Children's Hospital of Philadelphia, including human trials conducted across diverse therapeutic areas and routes of administration. "We at CCMT have persevered through more than a decade of scientific and clinical development and are now closer than ever to realizing the ambitious vision of one-time, potentially curative therapies to address serious genetic conditions. Spark Therapeutics is focused on the development of treatments for genetic diseases. Detailed information on company financials and operating reports can be found here: . Audentes Therapeutics (BOLD) is a clinical stage biotechnology company focused on developing and commercializing gene therapy products for rare diseases that are caused by single gene defects.. Spark Therapeutics, a fully integrated company, strives to challenge the inevitability of genetic disease by working to discover, develop and deliver gene therapies that address inherited retinal diseases (IRDs), neurodegenerative diseases, as well as diseases that can be addressed by targeting the liver. Spark Therapeutics has an overall rating of 4.4 out of 5, based on over 72 reviews left anonymously by employees. R&D in Biotech, Environmental and various industries (no marketing product yet) Tags Biotechnology, Healthcare Venture Deals, Healthcare IPO Companies managed Acquired/Merged Spark Therapeutics Headquarters 3737 Market Street Suite 1300 Philadelphia, PA 19104 US (888) 772-7560 info@sparktx.com Web Site N/A Milestones Related Companies PHILADELPHIA, Oct. 22, 2013 /PRNewswire/ --Spark Therapeutics, a new, fully integrated company developing gene-based medicines for a wide range of debilitating diseases, announced today it has launched with a $50 million capital commitment from The Children's Hospital of Philadelphia (CHOP) to advance and commercialize multiple ongoing programs with clinical proof of concept. High, M.D, a gene therapy pioneer who has served as the director of the CCMT since its inception. Spark's most advanced product candidate,SPK-RPE65, is in a fully-enrolled pivotal Phase 3 clinical trial for the treatment of a rare blinding condition. How much funding has this organization raised over time? About. Hemophilia Bis a rare genetic blood disorder that affects approximately 4,000 males in the U.S. and 26,000 malesworldwide. WhatsApp acquired by Facebook). Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. Shire. There is currently no pharmacologic treatment for this form of inherited retinal degeneration, which ultimately causes irreversible blindness. Spark Therapeutics Inc is a United States based company operating in the field of gene therapy. Notably, Spark has exclusive rights to commercialize CHOP's proprietary manufacturing technology and will use clinical-grade gene therapy vectors produced by the CCMT's state of the art good manufacturing practices (cGMP) clinical facility. This feature is in beta and may change with future updates. Its products include LUXTURNA (voretigene neparvovec) for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy and viable retinal cells. Spark Therapeutics' relocation gives more space to the laboratory functions with approximately 22,700-square-feet of lab space, 14,800-square-feet of office/meeting/amenity space, and an additional11,200-square-feet of building support and core on the second floor and 9,000-square-feet on the garden level. from 8 AM - 9 PM ET. PHILADELPHIA, PA, USA I February 01, 2021 I Spark Therapeutics, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY) and a fully integrated, commercial gene therapy company dedicated to challenging the inevitability of genetic . There are 69 replacement spark plugs for Champion CJ7Y. This study builds on the Spark team's previous groundbreaking work in advancing the first two gene therapy clinical studies in hemophilia B, the second of which achieved the highest levels of factor IX expression of any gene therapy trial to date. Current treatment requires recurrent intravenous infusions of either plasma-derived or recombinant Factor IX to control bleeding episodes. The team at Spark has incredible goals for the treatment of diseases including hemophilia B and inherited blindness, and we look forward to working with them to deliver groundbreaking new treatments to patients in need.". Spark's hemophilia B program has the potential to build on our leading hemophilia portfolio and could offer patients with this bleeding disorder a potential new treatment option.". "We are excited to announce our collaboration with Pfizer, as we believe it marks an important step towards bringing a potentially life-altering therapeutic to patients with hemophilia B," said Jeffrey D. Marrazzo, co-founder and chief executive officer of Spark. We are a force of over 90,000 people working together across more than 100 countries. The company is also advancing toward the clinic with gene therapy programs to address neurodegenerative diseases and additional hematologic disorders and other forms of inherited blindness. Spark Therapeutics, Inc. is a gene therapy company. Read more Corporate responsibility SPK-CHM and SPK-FIX are potential blockbuster products. Spark Therapeutics was founded in 2013 and became a Member of the Roche Group in 2019. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/spark-therapeutics-announces-gene-therapy-collaboration-in-hemophilia-b-with-pfizer-inc-300005849.html, Cision Distribution 888-776-0942 Sep 2015 - May 20171 year 9 months. Search this spark plug cross reference with more than 90000 models . Spark's initial focus is on treating orphan diseases where no, or only palliative therapies, exist. Use an on-page search by manufacturer code or . Spark Therapeutics, Inc. Feb 2020 - Dec 2020 11 months. Spark is a gene therapy leader seeking to transform the lives of patients suffering from debilitating genetic diseases by developing one-time, life-altering treatments. "The creation of Spark is the culmination of a decade-long commitment by CHOP and our founding team to drive the field of gene therapy forward during a time when many in the industry had moved away," said Jeffrey D. Marrazzo, co-founder, president and chief executive officer of Spark Therapeutics. Spark Therapeutics peak revenue was $93.5M in 2021. View contacts for Spark Therapeutics to access new leads and connect with decision-makers. It is a subsidiary of Hoffmann-La Roche. Pfizer is a leader in hemophilia, developing the first recombinant Factor IX product," said Dr. Katherine High, a hematologist and co-founder, president and chief scientific officer of Spark. In hemophilia B, the company's Phase 1/2 study is enrolling up to 15 subjects who will receive a one-time dose through an intravenous infusion of the gene responsible for expressing factor IX. Dr. High, who pioneered the development of AAV-mediated gene therapy for hemophilia, noted, "Pfizer's longtime experience in hemophilia, including strong relationships with physicians, patients and payors, as well as clinical, regulatory and commercial capabilities, will complement our team's deep knowledge of AAV-mediated gene transfer for the disease. The Company focuses on treating orphan diseases. Many of the CCMT's leaders will assume management roles within Spark or engage with the company as scientific advisors, including Katherine A. "This agreement reinforces Pfizer's longstanding commitment to the hemophilia community. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. This program leverages a long track record of hemophilia B gene therapy research and clinical development conducted by Spark and its founding scientific team over the past two decades. It has a pipeline of product candidates targeting multiple rare blinding conditions, hematologic disorders and neurodegenerative diseases. Jul 2013 - Jul 20141 year 1 month. Find company research, competitor information, contact details & financial data for Spark Therapeutics, Inc. of Philadelphia, PA. Get the latest business insights from Dun & Bradstreet. The company's expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Spark's team while at The Children's Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. $64.7 M FY, 2018 Market Capitalization $4.4 B 2019-12-17 Company summary Overview Spark Therapeutics is a gene therapy company. Limited products and pipeline Career advancement opportunities limited. To learn more, visitwww.sparktx.com. This study provides information about the sales and revenue during the historic and forecasted period of 2021 to 2030 Washington D.C. Metro Area Alexion Pharmaceuticals, Inc. . Funding Rounds Number of Funding Rounds 2 Total Funding Amount $122.8M Spark Therapeutics has raised a total of $122.8M in funding over 2 rounds. Spark will be responsible for conducting all Phase 1/2 studies while Pfizer will assume responsibility for pivotal studies, any regulatory approvals and potential global commercialization of the product. Spark Therapeutics, Inc. These include Viewport Meta, IPhone / Mobile Compatible, and SPF. The organisation is a fully integrated, commercial company committed to discovering, developing and delivering gene therapies for genetic diseases, including inherited retinal disorders, haemophilia, lysosomal storage disorders and neurodegenerative diseases. The open-label, randomized, controlled study builds on an earlier clinical study in which 12 patients with RPE65-related blindness demonstrated notable improvement in visual function, moving in some cases from being profoundly blind to being able to recognize faces and ambulate independently. Spark Therapeutics is comprised of over 800 employees with its headquarters situated in Philadelphia, USA. Spark is entitled to receive double-digit royalties based on global product sales. Fully Integrated Gene Therapy Company with Deep Clinical Pipeline Spun out of The Children's Hospital of Philadelphia. "Gene-based medicines are among the most complex therapeutics ever developed," said Dr. High. Genable Technologies Ltd. acquired by Spark Therapeutics, Stock ticker symbol (e.g. October was an important month for Spark Therapeutics . All school-age patients enrolled in the trial were able to transfer from Braille classrooms to sighted classrooms. We have built a fully integrated company, combining our proprietary adeno-associated viral (AAV) gene therapy platform with excellence in R&D, manufacturing and . Spark's team has more than 120 years of combined experience addressing the clinical, regulatory and manufacturing issues related to gene-based medicines. Active, Closed, Last funding round type (e.g. Spark Therapeutics uses 27 technology products and services including HTML5, Google Analytics, and jQuery, according to G2 Stack. About Spark Therapeutics Spark Therapeutics is developing potentially curative, one-time gene therapy products to transform the lives of patients and re-imagine the treatment of debilitating diseases. The founding team includes scientists who have led the advancement of gene therapy . After extensive research and analysis, Zippia's data science team found the following key financial metrics. "We believe Pfizer is the ideal partner for our hemophilia B program. Spark Therapeutics is an equal opportunity employer. from 8 AM - 9 PM ET. This rating has been stable . Hemophilia B is a serious and rare inherited hematologic disorder, characterized by a mutation in the Factor IX, or FIX, gene, which leads to deficient blood coagulation and an increased risk of bleeding or hemorrhaging. Its pipeline includes a product candidate targeting choroideremia (CHM), which is in a Phase I/II clinical . Spark Therapeutics, Inc. is a developer of gene therapy treatments, which treat debilitating genetic diseases. They acquired Genable Technologies Ltd. for $15.2M. To learn more please visit the Spark website at www.sparktx.com/pipeline/hematologic-disorders. Name of the organization that made the acquisition, Stock ticker symbol (e.g. Sparks expertise across research, clinical, regulatory and manufacturing builds on a legacy of innovation and excellence in gene therapy established by Sparks team while at The Childrens Hospital of Philadelphia Center for Cellular and Molecular Therapeutics. Spark's most advanced product candidate, SPK-RPE65 . 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